ALMA Ventures Platform

Mental health · Brain health · Longevity

Investing in the future of mental and brain health technology.

From prevention and early detection to treatment, recovery, resilience and longevity.

Born in Israel · Built for the worldTel Aviv · New York · Los Angeles

1B+people live with a mental health conditionWHO, 2025
In partnership and collaboration with
Sheba Medical CenterARC Innovation at ShebaDDR&D (MAFAT)

The platform

Turning Israel's breakthrough science into care for the world.

One mission, two independent paths. ALMA Ventures invests in companies building the future of mental and brain health. ALMA Foundation advances research and evidence for the entire field — open to every innovator.

Each organization is independently governed and funded, and pursues the shared mission on its own terms.

ALMA Ventures

We don't just back companies. We build them.

We invest in Israeli-linked, science-first companies that scale globally — and bring what capital alone cannot: clinical access, validation and a path to the payer.

Institutional access

First-look deal flow and clinical pilots through the ALMA network.

The living lab

National-scale need compresses validation from years to months, de-risking each investment.

Company building

Clinical pilots, regulation, reimbursement and US go-to-market — alongside the capital.

Impact, measured like returns

Clinical outcomes agreed at investment and reported alongside the financials, every year.

ALMA Foundation

In mental health, evidence is the product. ALMA produces it faster.

The Foundation supports the science and the first pilots that the market leaves unfunded — and turns every result into evidence the field can use.

Research Implemen-tation Data Evidence THE EVIDENCE LOOP Every pilot makes the next one faster
Research

Funds the clinical questions that come from hospitals and academia — with research partners in Israel and abroad.

Implementation

Runs structured pilots inside real care settings — hospitals, health systems, community services.

Data

Captures outcomes on validated scales and builds a shared data asset for the field.

Evidence

Turns results into proof that clinicians, regulators and payers accept — shared openly, in Israel and worldwide.

Three levels of evidence

Level 1Clinical

Efficacy on validated scales such as PHQ-9, GAD-7 and PCL-5.

Level 2Applied

Works in real settings: adoption, clinician capacity, time to first care.

Level 3Patient impact

Quality of life, people reached, lives improved.

Our goal1M+people gaining access to better mental and brain health care by 2035 — through the solutions the Foundation helps validate.
Clinical outcomes

Every solution must measurably improve real outcomes — proven in trials, not promised.

Capital catalyzed

Private and public funding attracted for every philanthropic dollar, tracked and reported.

Knowledge exported

Israeli-validated protocols and tools adopted by health systems worldwide.

Fund a program, help hundreds.
Fund the system, reach millions.

Why now

Four shifts are making mental and brain health measurable.

The largest unmet need in healthcare is still diagnosed by observation. That is changing — and the change is investable.

1B+people live with a mental health conditionWHO, 2025
$6Tprojected annual global cost of mental ill-health by 2030WEF / Harvard
$1Tin lost productivity a year from depression and anxietyWHO
2.1Bpeople over 60 by 2050WHO
The brain can now be measured

Brain age from a single MRI. EEG built into headphones. The first FDA-cleared blood test for Alzheimer's.

FDA, May 2025
AI became a clinical tool

The first randomized trial of an AI therapy chatbot cut depression symptoms by 51%.

NEJM AI, 2025
Prevention became something people pay for

GLP-1 drugs showed that millions will pay out of pocket to prevent disease, not only treat it.

 
Mental health, brain health and aging are merging

45% of dementia cases are linked to modifiable factors, including depression and isolation. The same companies now serve all three.

Lancet Commission, 2024

Why Israel

The world's living laboratory for trauma, recovery and human adaptation.

A nation of ten million under sustained pressure, with world-class science and hospital systems. Solutions are built, tested and deployed under real demand — then taken to the world.

“Israel didn't choose to be a living lab. Reality made it one.”Adi Ostry Matalon, Co-Founder · Ynet, 2026

3MIsraelis with PTSD or anxiety symptoms since October 7, 2023Israel Ministry of Health, Mental Health Division, 2024
1.5 yraverage wait for public mental health careState Comptroller of Israel, 2025
#1in clinical trials per capita for mental and brain health technologyStartup Nation Central, 2026
178active Israeli companies in the field — 80% of them early stageStartup Nation Central, 2026
$352Mraised by Israeli mental health tech in 2025 — up 150%Startup Nation Central, 2026
Weeksfrom concept to clinical pilot inside a partner hospital, where the standard path takes yearsHospital-embedded validation

TraumaTech

From Israel's experience to the world's resilience.

Israel has built more know-how in trauma, recovery and resilience than almost anywhere on earth. ALMA is helping turn it into a field.

Defining the field

Technologies for trauma, PTSD, chronic stress and recovery — from early detection to treatment.

Building bridges

Joint research, pilots and partnerships between Israeli innovators and health systems, universities and funders worldwide.

Convening the field

Bringing founders, clinicians, researchers and investors together across borders.

Who it serves in Israel
  • Survivors and bereaved families
  • The wounded and reservists
  • First responders and medical teams
  • Evacuated communities
  • Children and educators
Who it serves around the world
  • Veterans and their families
  • Refugees and the displaced
  • Communities after attacks and disasters
  • The clinicians who treat them

Where we invest

From early signal to deep intervention.

The convergence of mental health, brain health and longevity is creating a new category — and a new kind of company.

Diagnostics & prevention

Digital biomarkers, cognitive screening and continuous monitoring.

Care infrastructure & triage

Intake, triage and outcomes platforms that extend clinical capacity.

Digital & hybrid therapeutics

Software and clinician-plus-digital care built for reimbursement.

Neuromodulation

Stimulation, closed-loop systems and brain–computer interfaces.

Deep intervention & assisted care

Platforms for treatment-resistant care — including the delivery and monitoring platforms behind psychedelic-assisted therapy.

Conditions we address
Anxiety & depressionTrauma & chronic stressAddictionBurnout & performanceLoneliness & isolationWomen's health & hormonesAging & cognitionYouth & adolescents

Our team

Venture, science and medicine — in one team.

Venture exits, clinical leadership at Sheba and Columbia, and deep expertise in AI and neurotechnology. The team reflects the category it is building.

Adi Ostry Matalon

Adi Ostry Matalon

Co-Founder · Managing Partner

Investment strategist, 18+ years across finance, strategy and innovation. Former senior executive at international banks and impact funds; advisor to public bodies, health organisations and philanthropic foundations.

Esther Barak Landes

Esther Barak Landes

Co-Founder · Managing Partner

25+ years in VC leadership and venture creation. Exits include Playtika, Payoneer, Prolor and Orthospace. Chair, Wings IL · CEO, IMA Foundation.

Prof. Amitai Ziv

Prof. Amitai Ziv, MD

Co-Founder · Investment Committee

Director, Integrated Rehabilitation Hospital, Sheba Medical Center. Founder & Chairman, MSR — Israel Center for Medical Simulation.

Michal Arad, PhD

Michal Arad, PhD

Venture Partner

Scientist-investor, PhD in behavioral neuroscience. Strategic leader, ScienceAbroad · former VP, AWZ Ventures · CSO, NEXVOX.

Sarah Baradaran Becker

Sarah Baradaran Becker

Principal · Head of US

Product leader, 10+ years in language and vision AI (Smartling, exit to Battery Ventures). Board member, Nazarian Family Foundation.

Scientific, clinical & investment advisors

Prof. Talma Hendler

Prof. Talma Hendler, MD, PhD

Psychiatry & Neuroscience

Founding Director, Sagol Brain Institute · Co-founder, GrayMatters Health · Head, Psychedelic Research Institute, TAU.

Prof. Milton Wainberg

Prof. Milton Wainberg, MD

Psychiatry

Professor of Clinical Psychiatry, Columbia University / NYS Psychiatric Institute · Director, Mental Wellness Equity Center.

Dr. Orna Berry

Dr. Orna Berry

AI & Health

Director of Technology, Office of the CTO, Google, focused on mental health and PTSD · Former Chief Scientist of Israel.

Dr. Alona Barnea

Dr. Alona Barnea

Neurotechnology

Neuroscientist (PhD, Oxford; postdoc, Rockefeller). Director, Neurotechnology Division, MAFAT.

Prof. Eran Halperin

Prof. Eran Halperin

AI & Health

Professor, NYU (Computer Science) and NYU Langone (Precision Medicine) · formerly UnitedHealth / Optum.

Yonit Serkin

Yonit Serkin

Venture Building

Scaled 350+ startups. Former CEO, MassChallenge Israel · Co-founder, Moonscape Ventures.

The future of mental and brain health will be built by those who choose to build it today.

Investors, families and foundations, clinical and public institutions — there is a way in for each. Let's talk.